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ASEA Study Shows Signaling Pathways in Genes After Consuming Redox Supplement

ASEA Redox Signaling SupplementASEA announces results of double-blind placebo based study on its Redox cell signaling supplement.

This initial study shows ASEA Redox signaling supplement to signal human genes, which have “shut off” due to stress, toxins, age, etc., and turn them back on.

ASEA partnered with Taueret Laboratories, a leading genetic research laboratory, to conduct an observational study to understand how ASEA REDOX affects the activation of human genes. The eight-week human study was reviewed and approved by Quorum Review Independent Review Board, ensuring the ethical integrity, safety, and control of the research study. The study was a randomized double-blind placebo controlled study.

60 participants were randomly placed into three groups, 25 in an active group (ASEA REDOX), 25 in a placebo group (saline placebo), and 10 in a control group (did not drink either ASEA REDOX or placebo). The placebo was derived from the same saline solution used to create the actual ASEA REDOX for this study, but did not contain ASEA’s patented redox molecules.

Of the 60 participants, 41% were male and 59% were female, with the mean age 35.  Each participant, except for the control group, drank 4 ounces of ASEA REDOX or placebo twice daily.

Participants had blood drawn at the beginning of the study and again at week eight of the study. Serum RNA was extracted using a PreAnalytix PAXgene Blood RNA Kit. Gene expression levels were then tested using Affymetrix PrimeView Array and differential expression within and between groups analyzed.


Results of the eight-week study showed a 20 – 31% difference in gene expression abundance in five genes that are involved in pathway signaling, including regulatory network pathways. Long-term consumption of ASEA REDOX resulted in stable expression changes at the eight-week time point (figure 1). These genes are key in the health of the individual and play a vital role in five human health areas and dozens of pathways.

Pathway signaling genes are unique as they have the potential to influence a multitude of biological responses. Analysis of the five genes was provided through two pathway analysis programs, PANTHER (Protein ANalysis THrough Evolutionary Relationships) and WikiPathways. An example of a gene product that was expressed in this study that interacts with multiple important pathways is the EGR1 gene.

In order to better understand how the genes reacted post-study, the ASEA REDOX group that saw the 20 – 31% change provided blood samples eight weeks post-study. The results demonstrated that all the changes seen while on the product had reverted back to their pre-study levels.


• The initial study data suggests that five genes   expressed a change in transcript abundance.

• The ASEA REDOX group saw gene activation results in  regulatory pathway related genes that signal dozens of  important biological functions.

• The ASEA REDOX and the placebo (saline) behaved  differently.

• There were no harmful changes in the gene expression  trends of the participants consuming either beverage  during the course of the study. This is representative of  long-term safety.

• Daily consumption of ASEA REDOX over eight weeks  appears to result in stable expression changes.

• Changes in gene expression eight weeks post study in  the ASEA REDOX group were no longer observed. This  suggests continued use of ASEA REDOX is necessary to  sustain the observed gene expression results.

• Effects of consuming ASEA REDOX are systemic.

• Effects are non-specific to race, sex or age, and were  observed in all populations tested.


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ASEA Announces New Product Launch

For nearly five years ASEA has planted itself firmly as a solid growth company in the network marketing industry. This past weekend in Las Vegas the company held its annual convention where it announced a new breakthrough product in the arena of Redox Signaling.

RENU 28 is a topical gel for the skin using the power of redox signaling molecules and nano technology.

RENU 28 encourages the strength and resiliency of your skin cell reproduction in partnership with your body’s natural efforts to keep your skin healthy. The powerful science behind RENU 28 delivers gentle, effective treatment to repair and comfort aging or damaged skin. Through Redox Signaling technology, this unique gel provides essential support to the all-important cellular mechanisms that are the foundation of your skin’s structure. Vital to the health of living cells, RENU 28 provides critical connections and communication between cells with Redox Signaling molecules to ensure optimum renewal and replenishment.

RENU-28-ASEA-4-dermatest-300x166Dermatest, one of the leading dermatological research institutes in the world, gave RENU 28 its coveted 5-star clinically tested seal. In clinical trials, twenty women used RENU 28 for 28 days. In addition to standard dermatological tests, digital scans were made of individual features such as wrinkles and skin texture.

Redox Signaling Molecules are naturally created within every cell of the body. They are vital to your immune system and to the cellular healing mechanisms of your body. A proper supply of Redox Signaling Molecules enables cellular healing throughout your
body. As you age, your cells make fewer and fewer of these molecules and your body’s ability to combat everyday ailments and the effects of aging diminishes.

In order to keep the cellular mechanisms of your body performing properly, it is essential that you supplement and replenish these Redox Signaling Molecules. The only way that you can do that is through ASEA—the world’s only source for Redox Signaling Molecules.

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ASEA to be Title Sponsor for 2013 Utah Valley Marathon

Utah Valley Marathon 6-2010 032ASEA is the title sponsor of the 2013 ASEA Utah Valley Marathon! Held June 8, 2013, the ASEA Utah Valley Marathon will introduce thousands of people from around the country to ASEA.

“We are thrilled to partner with the ASEA Utah Valley Marathon to bring this great event to our community,” said Tyler Norton, Founder and CEO of ASEA.  “ASEA’s core mission is to enhance the wellness of people everywhere, and we’re pleased to sponsor this event that encourages so many people to be active.  Our sponsorship of this race will allow us to introduce the benefits ASEA to thousands of people who are interested in a healthy lifestyle.”

Starting in the stunning Wasatch Mountains, the race course passes cascading waterfalls and beautiful mountain scenery, finishing in downtown Provo, Utah.  The ASEA Utah Valley marathon includes races for all levels including a full marathon, half marathon, 10K, and Kids 1K.

To register for the ASEA Utah Valley Marathon, CLICK HERE

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Redox Signaling Made Easy (and Fun)

This simple video is an engaging and novel way to look at the power of Redox Signaling Molecules and how ASEA has captured this incredible science in a bottle.

Please share your comments, questions, or insights!

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There’s Science in ASEA

Prepared by: Gary Samuelson, Ph.D. Robertson D. Ward, M.D., FAAFP David Carpenter, N.D., C.Ac., C.C.I.

The North Carolina Research Campus, and the Appalachian State University Human Performance Laboratory, under the direction of Dr. David Nieman’s world renowned team of scientists, uncovered new findings proving that the consumption of ASEA empowers humans to shift the availability of free fatty acids. These calorie sources represent a more favorable and efficient source of fuel for exercise and all daily life activity.

Facts about Our Metabolism

Cells inside our body breathe! The processes of metabolism at a cellular level involves the consumption of molecular oxygen and large molecule energy sources (sugar, glycogen, fatty acids, and amino acids). Through the process of oxidative phosphorylation (cellular respiration…breathing!) the cells create energy (ATP). The mitochondria in our cells do this work, and this is where Redox Signaling molecules are created.

Metabolism and Athletes

We understand that our cells always strive to run at the greatest efficiency possible. Through the conditioning of our bodies, our cells learn to use certain fuel sources preferentially. We are all familiar with the fatigue and pain that happens after rigorously exercising out-of-shape muscle groups. This happens because the muscle exhausts the standard glycogen source for fuel and then shifts to anaerobic metabolism (using fuel without oxygen), which forms lactic acid metabolites. But trained distance runners have conditioned their bodies to utilize a different fuel source: fatty acids (which are 6 times more energy-providing than other sources). By using fatty acids, these athletes preserve their muscle glycogen stores for strenuous bursts, like at the end of races, and that means greater endurance.

This is important. Endurance athletes actually condition their bodies to use fatty acids as a preferred fuel source, sparing muscle glycogen and increasing endurance.

Specific Metabolite Research Findings with ASEA:

The astonishing results of this randomized, double-blinded, crossover, placebo-based research showed that after one week of drinking 4 ounces of ASEA daily, the test subjects demonstrated a shift in 43 of 108 metabolites measured from the blood sample. These shifts were revealed using ultra-sensitive mass-spectroscopic measurement techniques. These shifts were so great that it was thought that there might be a software anomaly and scientists requested a manual inspection to verify data.

The largest metabolite shifts were in serum fatty acids. Again, these shifts happened after one week of consumption and before any athletic activity. Fatty acids are typically mobilized from abdominal body fat stores. They included myristic acid, palmitic acid, oleic acid, stearic acid, palmitelaidic acid, and capric acid. Don’t let the “acid” part throw you off; these are sources of fuel for the human body.

The chemical markers of these fatty acids are called “metabolites,” and their various concentrations in our blood represent a fingerprint of our metabolic balance. The metabolite shifts found due to ASEA ingestion are profound and very beneficial to health, since these shifts mimic what the body does when seeking fuel efficiency; that is, using fatty acids as a preferred fuel source and sparing muscle glycogen.

These important metabolite changes have resulted in applications for new patents for ASEA, and have prompted further studies at the North Carolina Research Campus. Additionally, all of these changes occurred without any evidence of toxicity whatsoever on any basic organ functions in liver and kidney tissue.


These initial results from a larger study on athletic performance have demonstrated that ASEA, which is composed of Redox Signaling molecules, has a profound impact on mobilization of fatty acids as they aid with efficiency in cellular respiration. This favorable pattern of increased availability of fatty acids for fuel consumption represents a foundational shift in our metabolic fingerprint – a shift toward more effective patterns of fuel usage and energy output.

ASEA and its foundational technology are completely protected by U.S. patents5,334,383;  5,507,932;  5,674,537;  5,731,008;  6,007,686;  6,117,285.

ASEA athletes are finding they can go farther, faster, longer without red-lining their heart rate or going into critical oxygen debt

  • Redox Signaling molecules are the key to cell efficiency
  • ASEA athletes increase cell efficiency, giving them a competitive advantage
  • Clinical studies show 12% average increase in time to VT (ventilatory threshold)
  • Tested athletes report shorter recovery time and less soreness and fatigue
  • Clinically proven, 100% safe, completely free of banned substances
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ASEA Science – Metabolites

Research conducted by the renowned Human Performance Laboratory at Appalachian State University, validates what ASEA drinkers all around the world already know: ASEA has profound positive benefits to the body. In fact, the research findings were so profound that even the scientists doing the research were astonished by the results.

We blogged about this research over a week ago, but for those of you who prefer to watch the movie rather than read the book, here’s a new video just released where those involved in the research tell the incredible story.

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Clinical Trials Now Showing ASEA Advantages

Study finds that after drinking ASEA for one week, athletes experienced shift in 43 metabolites

Salt Lake City, Utah — ASEA, LLC announces the release of groundbreaking findings at the Experimental Biology 2012 Conference in San Diego of a new study from the Human Performance Laboratory showing increased power output and endurance among competitive athletes.*

David C. Neiman DrPH, FACSMThe study supervised by Dr. David C. Nieman, DrPH, FACSM at the Human Performance Laboratory, Appalachian State University, found that after drinking ASEA athletes experienced massive free-fatty acid mobilization in the blood PRIOR to exercise to a level normally found only after heavy exercise.

“These are very significant findings,” said Nieman. “Our research demonstrated that ASEA is causing mobilization of free-fatty acids PRIOR to exercise, making this source of fuel available at the outset of exercise or competitive performance. This has important implications, especially regarding glycogen sparing, which is something every athlete tries to achieve.”
Glycogen sparing is the use of non-carbohydrates as a source of energy during exercise so that the depletion of muscle glycogen is delayed. When glycogen is spared the body burns fats for energy, making a greater contribution to an athlete’s efforts during the initial stages of a race. This leaves more glycogen for the later stages of racing or exercise, and muscle fatigue will be delayed.

The research found that after drinking ASEA for one week, athletes were experiencing a shift in 43 metabolites.

“We have rarely seen such a drastic difference. For 43 of those signals to change, that is a quarter of the metabolite profile that we are monitoring. It is a huge bump in metabolite shifts that are due to the ingestion of just one product,” said Nieman.

What do these metabolite shifts mean for athletes?

“Athletes actually started the exercise after drinking ASEA with a lot more of these free-fatty acids in their blood. The reason that is important is that the muscles will actually use that as fuel, sparing the muscle glycogen and the use of amino acids which is what we found as we analyzed the data,” said Nieman.

“Every understanding from the literature is that these probably came from the fat stores in the abdominal area,” said Nieman. “So if you drink ASEA we found that the fats go up in the blood. If you’re not exercising, those fats will still be used to support the body’s metabolism for life.”

Simply drinking ASEA for seven days mobilized fuel stores in the body from abdominal fat. For those that want to burn more fat during exercise ASEA is ideal. Even without exercise the freed up fat stores will be used by the body as fuel.

Although this is the first laboratory study of ASEA on athletes, many endurance athletes have been drinking ASEA and noticing improvements in their race times, recovery after racing/training, etc.

James Lawrence IronmanJames Lawrence, World Record, Most Triathlons 70.3 races, said, “I’ve experienced all these tremendous benefits over the last few years when I’m doing all these world records, and maybe didn’t understand it, but was fearful to go off the product. With this new study it’s really helped me understand why I don’t get sore, and why I’m able to just lock in this strong pace and hold it for so long.”

cody waiteCody Waite, professional Xterra triathlete, had this to say about Dr. Nieman’s study. “My thoughts on the study are that I kind of already knew this through my own experience with the product. But at the same time it’s great to have that solid evidence that laboratory test make official. That gives it that official stamp of approval from the scientists and then the stamp of approval from lead athletes.”

diana macmanusDiana MacManus, three-time national swimming champion said, “With ASEA I’ve noticed that my times and my meets have improved significantly. Learning about the research behind ASEA boosts my confidence and reinforces what I already know.” Typically, muscle glycogen is reduced in the body during a single or many groups of energy expenditures. For example, during a single sprint muscle glycogen may deplete by 25% to 30% of the resting levels. Similarly, at the end of longer durations (60 to 90 minutes) of high, moderate and low exercise muscle, glycogen will be dramatically reduced or depleted.

The study included 20 fit athletes in a randomized, double-blind, placebo-based, cross-over study. After baseline testing for VO2Max and body composition, one-half of the athletes drank four ounces of ASEA each day for seven days. The other one-half of the athletes drank four ounces of a placebo for seven days. Then all athletes completed a 75-km cycling trial, with blood drawn prior to the trial, immediately after the trial and one hour after the trial.

After a “washout” period in which none of the athletes drank ASEA or the placebo, a seven day cross-over study was conducted. The original ASEA group drank the placebo and the original placebo group drank ASEA for a seven day period. Then all athletes completed a second 75-km cycling trial, with blood drawn prior to the trial, immediately after the trial and one hour after the trial.

The research demonstrated that drinking ASEA taps into the body’s largest energy reserves, freeing fatty acids from adipose tissue, BEFORE exercise or athletic competition.

“This unexpected mobilization of fatty acids in theory will lead to better endurance in athletes, assisting athletes to maintain a certain pace for longer periods of time,” said Nieman.

The research found that the release of fatty acids is coming from fatty adipose tissue, the body’s source of abundant, available energy. Adipose tissue is fat stored around the organs of the body, with the most common and largest fat store being the abdominal area. Adipose tissue triglycerides represent the largest energy reserve in the human body. Utilizing these stores is critical for prolonged endurance exercise.

The study also demonstrated that the athletes in the study experienced a massive increase in blood levels of ascorbic acid (vitamin C) after exercise. This could indicate less oxidative stress on muscles. Further research is being conducted to determine the implications of this increase.

“This study is the latest in ASEA’s commitment to ongoing research. The frontiers of redox signaling molecules and ASEA are constantly being pushed. This latest study is not a destination, but an on-ramp,” said Verdis Norton, Chief Executive Officer at ASEA.

Human Performance Laboratory

ASU/NCRC Human Performance LaboratoryThe mission of the ASU/NCRC Human Performance Laboratory is to investigate the influence of unique plant molecules (e.g, flavonoids such as quercetin, luteolin, and epigallocatechin 3-gallate or EGCG) on age-related loss of muscle mass (sarcopenia), muscle mitochondrial biogenesis, and exercise-induced changes in immune function, oxidative stress, and inflammation. The Human Performance Laboratory is located at Appalachian State University North Carolina Research Campus and is affiliated with the North Carolina Research Institute which brings together eight universities as well as researchers at Dole, General Foods and Monsanto.

The Company and Product

ASEA, LLC is a Salt Lake City-based company whose flagship product, also called ASEA, is the world’s first and only source of stable, balanced, native-to-the-body Redox Signaling molecules.

ASEA is sold in a 32-ounce bottle and an eight-ounce flexible pouch made from environmentally friendly materials. The 32-ounce bottle is made from a durable plastic. The eight-ounce flexible pouch fits easily into a backpack, pocket or in athletic gear. Both packages were created from input from competitive athletes and everyday ASEA consumers. The eight-ounce pouch includes a one-way valve to keep the pouch contents clean and pure.

ASEA can be purchased through ASEA’s wide network of independent associates.

ASEA and Redox Signaling Molecules

ASEA, with its Redox Signaling technology, is a powerful new drink that helps both competitive and recreational athletes step up their game to new levels of performance.

ASEA is the original and only Redox Signaling product available today. It provides the body with two perfectly balanced sets of reactive molecules — the same molecules produced naturally by the mitochondria in every cell of the body. These vitally important molecules support the production of the ATP energy that fuels our cells, help activate antioxidants, minimize cellular damage, enhance cellular communication, and speed the healing response — all functions critical to athletic performance, endurance and recovery.

Redox Signaling is a burgeoning scientific field on a global scale with an impressive array of recent research advances. Only recently have ASEA scientists been able to produce stable mixtures of these Redox Signaling molecules outside living cells.

ASEA and its foundational technology is completely protected by U.S. patents  5,334,383;  5,507,932;  5,674,537;  5,731,008;  6,007,6866,117,285.

*These statements have not been evaluated by the Food and Drug Administration.  The product is not intended to diagnose, treat, cure or prevent any disease.  The North Carolina Research Institute and its members, including Appalachian State University, do not endorse any products.  The statements by NCRI scientists should not be construed as product promotion.

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ASEA Expands into Europe

A monumental announcement was made today at the ASEA Italy Grand Opening event in Rome.

Jarom Webb, ASEA COO, announced the opening of the Netherlands market and the launch of the Netherlands Distant Selling Program. Under this new program, ASEA product can be legally purchased and received through the Netherlands in six additional European markets: Germany, Spain, France, UK, Ireland, and Slovenia.

ASEA product will be shipped out of a distribution center in the Netherlands, and commissions will be paid in these markets under the global compensation plan.

For more information on ASEA as a business click here.

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Redox Signaling Found Critical to Curbing Cell Suicide

Recent findings of researchers at the University of Vermont College of Medicine show that Redox Signaling molecules are crucial in the regulation of apoptosis.

Antioxidants & Redox Signaling JournalThe study findings, published in volume 16 issue 6 of the Journal of Antioxidants and Redox Signaling state, “Redox-based signaling governs a number of important pathways in tissue homeostasis. Among the biological processes regulated by redox signaling, apoptosis or programmed cell death is a highly conserved process important for tissue homeostasis.”

The study further stated, “Apoptosis can be triggered by a wide variety of stimuli, including death receptor ligands, environmental agents, and cytotoxic drugs. Recent discoveries demonstrate that redox-based changes are required for efficient activation of apoptosis. Among these redox changes, alterations in the abundant thiol, glutathione (GSH), and the oxidative post-translational modification, protein S-glutathionylation (PSSG) have come to the forefront as critical regulators of apoptosis.”

“This is an important finding to support the importance of Redox Signaling Molecules. Apoptosis, a foundational cellular mechanism, is preserved at all cost,” said Robertson Ward, M.D., FAAFP, member of the ASEA Science Advisory Council.

ASEA, LLC is a Salt Lake City-based company whose flagship product, also called ASEA, is the world’s first and only source of stable, balanced, native-to-the-body Redox Signaling molecules.

Redox Signaling Molecules are produced naturally by the mitochondria in every cell of our body. But as people age they produce less and less of these molecules, which are vitally important to activating antioxidants, promoting cellular health, and enhancing cellular communication.

ASEA is the only method to re-introduce Redox Signaling molecules into the human body. It is sold in a 32-ounce bottle and an eight-ounce flexible pouch made from environmentally friendly materials.

The product can be purchased through ASEA’s wide network of independent associates.

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