Redox Signaling Found Critical to Curbing Cell Suicide

Recent findings of researchers at the University of Vermont College of Medicine show that Redox Signaling molecules are crucial in the regulation of apoptosis.

Antioxidants & Redox Signaling JournalThe study findings, published in volume 16 issue 6 of the Journal of Antioxidants and Redox Signaling state, “Redox-based signaling governs a number of important pathways in tissue homeostasis. Among the biological processes regulated by redox signaling, apoptosis or programmed cell death is a highly conserved process important for tissue homeostasis.”

The study further stated, “Apoptosis can be triggered by a wide variety of stimuli, including death receptor ligands, environmental agents, and cytotoxic drugs. Recent discoveries demonstrate that redox-based changes are required for efficient activation of apoptosis. Among these redox changes, alterations in the abundant thiol, glutathione (GSH), and the oxidative post-translational modification, protein S-glutathionylation (PSSG) have come to the forefront as critical regulators of apoptosis.”

“This is an important finding to support the importance of Redox Signaling Molecules. Apoptosis, a foundational cellular mechanism, is preserved at all cost,” said Robertson Ward, M.D., FAAFP, member of the ASEA Science Advisory Council.

ASEA, LLC is a Salt Lake City-based company whose flagship product, also called ASEA, is the world’s first and only source of stable, balanced, native-to-the-body Redox Signaling molecules.

Redox Signaling Molecules are produced naturally by the mitochondria in every cell of our body. But as people age they produce less and less of these molecules, which are vitally important to activating antioxidants, promoting cellular health, and enhancing cellular communication.

ASEA is the only method to re-introduce Redox Signaling molecules into the human body. It is sold in a 32-ounce bottle and an eight-ounce flexible pouch made from environmentally friendly materials.

The product can be purchased through ASEA’s wide network of independent associates.

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ASEA: FACT or FICTION

Guest Blog by Mike Bills
Posted by Permission

fact-fictionSince I have been doing this blog with my good friend Matt we often get asked a lot of questions regarding ASEA. A lot of the questions are from information seeking curious individuals that truly want to understand the message that we are trying to deliver. Other questions are from those trying to clear up misinformation and misunderstanding. Then still we have those that are extremely skeptical and think ASEA is a scam and they mean to trip us up. I do understand, I didn’t believe in ASEA until I saw it change lives with my own eyes. I have a very personal connection to this product.

I wanted to take a few moments and address some of the more common questions and also common misconceptions that I see when it comes to ASEA.

Fact or Fiction?: Redox Signaling was invented by ASEA to sell ASEA.

A: Fiction!

I wrote a blog article a while back titled “What is Redox Signaling” . In the article I encouraged individuals to Google Redox Signaling and determine for themselves the science. WOW! I was torn apart for not explaining it. My intention was that if you Google Redox Signaling you can find thousands of independent articles on Redox Signaling. This would show this emerging science of Redox Signaling is not concocted by ASEA. I wont make that mistake again. At the bottom of this article under Resources I will include several links to outside sources on Redox Signaling. In addition there are several books on Amazon dealing with the topic of Redox Signaling including Redox Biochemistry & a publication on Antioxidants & Redox Signaling.

Why spend so much time on Redox Signaling? The first step to understanding ASEA is to having a basic understanding in the Science Behind ASEA.

Fact or Fiction?: ASEA was created for a comp plan for a network marketing company.

A: Fiction!

I understand this question. A lot of network marketing companies are created by professional network marketers to be network marketing companies. They want to create a company so they develop a marketing plan and then go find the products to fill the comp plan. Their entire Differentiating Advantage is their comp plan. The product is an after thought.

If you watch the How ASEA was Founded Video or attend any Meet ASEA meetings where Verdis Norton and James Pack tell their story you will quickly learn that when Verdis and James acquired the technology behind ASEA the intention was to determine why it worked, then to sell the technology for a profit. In order to determine why ASEA was getting the results it was, Verdis found and enlisted the help of Atomic Medical Physicist Dr. Gary L. Samuelson. It was Dr. Samuelson that determined what ASEA was and why it was working. Once they had made this discovery they did intend to sell and had an offer from a pharmaceutical company. Dr. Samuelson begged Verdis not to sell the technology because it would “be lost to mankind” if he did. Verdis took Dr. Samuelson’s advice and later ASEA was born!

Fact or Fiction?: ASEA is protected by Patents

A: Fact

ASEA and its foundational technology are completely protected by U.S. patents 5,334,383; 5,507,932; 5,674,537; 5,731,008; 6,007,686; 6,117,285.

Click on the above patents and do your own due diligence!

Fact or Fiction?: ASEA is a formulation created in a lab and is synthetic.

A: ABSOLUTELY FICTION!

I would describe ASEA as a Discovery. Actually two major discoveries that are scientific breakthroughs.

First, ASEA has managed to create native to the body redox signaling molecules that are created by the mitochondria in each cell of your body – outside of the body!

Second, ASEA has stabilized these molecules in a bottle that allows you take drink or apply them topically to re-introduce them to the body. Your body sees them as Native!

To understand watch the ASEA Breakout Product Video

Fact or Fiction?: ASEA is a Scam

A: Most Definitely Fiction

I mentioned that at the beginning of this post I have a very personal connection to this product, let me explain. First, I am an independent ASEA associate, I am not an employee. I also do want to promote and sell ASEA for a profit. However it goes beyond that. I have personally seen great benefits to individuals both close to me and that I have met through this endeavor and I fell an obligation to share. There are those that have written many negative articles on ASEA on the internet and branding it as a scam. I will say that those individuals have not done their due diligence and have an agenda. In fact a couple of them we have reached out to, invited them to ASEA to find out for themselves, on our dime with no obligation just to see the truth. They have all declined.

I was first introduced to ASEA prior to the launch by members of my family. They had invested very large amounts of money and are shareholders of ASEA. They encouraged me to take a look at the product and the company as they had intimate knowledge being shareholders. They then connected me to the Daughter and the Son of the CEO Verdis Norton. Nancy Norton Thunell was the first distributor in ASEA, Member of the founders club, diamond founders club and is a Triple Diamond. I am happy to say she is my close friend and her and her brother Jon Norton work directly with me to share and promote this wonderful product.

I truly believe that if you share ASEA, you will make a significant substantial difference in the lives of someone that needs it. I have seen it over and over again.

Resources

Critical Care 10(208) (2006), “Reactive oxygen species: toxic molecules or spark of life?””, Shelden Magder (http://ccforum.com/content/10/1/208).

Biochemical Pharmacology 70 (2005) 811-823, “Redox regulation: A new challenge for pharmacology””, Daniel Frein, Stefan Schildknecht (http://www.ncbi.nlm.nih.gov/pubmed/15899473).

Redox signaling in biology and disease series intro, ““The expanding network of redox signaling: new observations, complexities and perspectives””, Roy J. Soberman (http://www.ncbi.nlm.nih.gov/pubmed/12618508).

J Radiat Res (Tokyo 2004) 45(3) 357-72 “Oxidative stress, radiation-adaptive responses, and aging””, Miura Y. (http://www.ncbi.nlm.nih.gov/pubmed/15613781).

Biochemistry (Moscow) 70(2) (2005), ““Mitochondrial Metabolism of Reactive Oxygen Species””, A Yu Andreyev (http://www.ncbi.nlm.nih.gov/pubmed/15807660).

Cardiovascular Research, v71, p247-258 (2006), “Redox Signaling in Hypertension”, Tamara M Paravicini (http://www.ncbi.nlm.nih.gov/pubmed/16765337).

Wound Rep Reg, v11 p431-438 (2003), “The general case for redox control of wound repair”, Chandan K. Sen (http://www.ncbi.nlm.nih.gov/pubmed/14617282).

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American Health Journal Reports on ASEA

Learn more about ASEA here.

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Patents and New Information on ASEA

As we age our body makes fewer signaling moleculesWe’ve had a number of requests for patent information on the manufacturing, process, and solution known as ASEA.

Currently 6 of the 30 medical and mechanical patents have been approved for use by ASEA and Independent Associates.  ASEA continues to work to obtain the necessary permissions to use additional patents, scientific studies, and research documented since the creation of this product even before it was known as ASEA.

However, this vital information is still tied up in bureaucratic red tape surrounding ASEA’s designation as a supplement rather than a drug.

The original science and research behind the product was done with the intention of creating a new pharmaceutical (drug).  When the original company developing the product ran out of money it was acquired by a biotech company that didn’t really know what it had in regard to the research, manufacturing process, and end product.  So it sold the entire works to Verdis Norton and James Pack, the founders of ASEA.  And, as they say, the rest is history.

Suffice it to say the patents have helped bring another layer of credibility to ASEA and Redox Signaling, the science behind which ASEA is based.

SO…with that the patent numbers are listed below which you can search at http://patft.uspto.gov/netahtml/PTO/srchnum.htm to get the detailed patent documents.

  • Category creator, one of a kind product completely protected by more than 30 U.S. patents including patent numbers  5,334,383;  5,507,932;  5,674,537;  5,731,008;  6,007,6866,117,285
  • 17 years and over 20 million dollars spent on research, development, and clinical study.
  • The world’s first and only Redox Signaling Supplement – Redox Signaling Molecules are Native to the body – Required by every BODY.
  • Company is less than 2 years old yet was profitable in its first year in an industry where 90% of start-up companies fail in their first year.
  • Company on track to double revenue in 2012.
  • Athletic performance and endurance benefit is driving the company to worldwide distribution. Once an athlete learns the advantage this product provides they will not be without it

Clinical studies:

  • Safe for ingestion and exhibits zero toxicity, based on standard safety biomarkers.
  • Athletic endurance, as measured by time to ventilatory threshold and time to VO2max , is significantly increased by more than 10% on average.
  • Helps speed recovery after athletic exertion.

Claims Supported by Research Institutions

  • Increases antioxidant efficiency of glutathione peroxidase and superoxide dismutase (SOD) inside living cells more than 500%.
  • Significantly stimulates the production of the master antioxidants inside the cells without causing an inflammatory response.
  • Significantly increases the efficiency of communication signals between cells, those involved in cell damage detection, cell repair, and cell replacement.

Product specific facts:

  • The only stable perfectly balanced mixture of reactive molecules that exist outside of the body.
  • The product of more than 16 years of research, showing it to be a safe and natural way to help your body function as it should.
  • The product components are native to the body and consistent with its natural chemical balance.
  • Supports immune system functions that reduce oxidative stress and repair cellular damage.
  • Accelerates the body’ production of its own natural antioxidants, like glutathione, superoxide dismutase (SOD), and catalase.
  • The only product that delivers the balanced foundation that every person must have to allow their body and immune system to function at the cellular level.
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Four Ways to Lose Weight Without Gym

“Eat less, exercise more.” While these wise words incorporate the most universally successful diet plan, there are several things you can do without hitting the gym to help your body fuel more efficiently. Here are four tips that will help you reach your weight goal: 

CATCH MORE ZZZ’S – Giving your body a full night’s rest is one of the best ways to shed weight. A recent study showed that when participants slept for only four hours consumed an extra 300 calories compared with when they slept a full eight hours! Sleep deprivation also curbs self-control. Plan ahead and wind down your night in time to provide adequate sleep. Its benefits go far beyond losing weight. 

HYDRATE, HYDRATE, HYDRATE – The human body is mostly water, which is incentive enough to be sure you’re getting the minimum eight glasses a day, but did you know water can help your diet? Drinking water helps to keep you feeling full, meaning less snacking. Downing ice water has the added benefit of boosting your metabolism, burning calories in the process of warming the water. A pre-workout hydration session will help your body release muscle-building hormones – and more muscle means a higher basal metabolic rate. If too much water bores you, look for healthy ways to change it up. A number of companies make flavored waters that are packed with helpful vitamins. Green tea has the added benefit of antioxidants and a metabolism boost that can add up to an extra 400 calories or more per week! 

WATCH PORTIONS – Being a conscious eater is a good habit to develop, regardless of dieting. It takes the body 20 minutes after eating to recognize it’s full. By knowing what a serving size should be and sticking to it, you’ll be able to avoid that overfull feeling and give your body the right amount of fuel. Remember, you can always come back for more food if you’re still hungry later. When eating out, where meals are regularly double or triple the size of what your body actually needs, it may be wise to ask for half your order to be boxed up to go – it’s a great way to curb mindless eating AND stretch your delicious dish for two meals. 

GET FIT WITH FRIENDS – Take positive peer pressure to the next level by checking in with friends or relatives who are also fitness minded. That healthy support system can help you make wiser lifestyle choices, from choosing more active entertainment options to skipping calorie-laden lunches or happy hours. If IRL (“in real life”) relationships won’t cut it, there are a number of free fitness forums online that provide nutrition information along with peer encouragement, from cyclist Lance Armstrong’s LiveStrong to MyFitnessPal, which recently reported a combined weight loss of 20 million pounds among its membership – simply by counting calories, exercising, and comparing notes.

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Shake up the grocery shopping routine

Tired of the same old, same old? Here are some out-of-the-box eats to incorporate into your diet, along with some stand-bys with benefits just too good to ignore: 

WATERMELON – If you need an excuse to load up on this summer favorite, here’s one: watermelon contains lots of nutrients and cancer-fighting antioxidants like lycopene and vitamin C. As if that wasn’t enough, it’s 92 percent water, meaning it will full you up with minimal calories. 

JICAMA – While this Mexican turnip may look like a fuzzy brown lump, beneath the surface is a fiber-packed snack that can work wonders for weight loss. With a high fiber-to-sugar ration and plenty of potassium (which the body requires for maintaining its water balance) – not to mention a delicious, light taste and crispy crunch – jicama is a winning snack to work into your diet.  

NUTS – There are few foods smarter than nuts. Not only are nuts like almonds and pistachios packed with monounsaturated fatty acids, which help you control your appetite while lowering your risk of heart disease and diabetes, but they also contain protein that will keep you full AND increase your calorie burning potential for up to three and a haf hours. Other nut benefits include increased vitamin E levels along with improved memory and performance. Not all nuts are created equal, so be sure to check out what’s best for your goals.  

PURPLE CARROTS – If you think regular ol’ carrots are a healthy eat, just wait until you try their purple cousins! In addition to the beneficial phytochemicals contained in the orange variety, purple carrots contain anthocyanins, powerful antioxidants with anti-aging properties. 

MANGOES – These delicious fruits hold a number of benefits in their juicy orange flesh. Sweet enough to curb sugar cravings, mangos are also high in fiber, iron, magnesium and antioxidants. They also aid in digestion, so make sure you opt for the fruit over just the juice. 

EGGS – The incredible, edible egg is making a comeback among fitness circles. Several studies have shown that egg protein outperforms other proteins in boosting muscle strength and development, thanks to its high concentration of the amino acid leucine. Egg protein also helps curb hunger over a sustained period of time while providing plenty of energy.  

MULBERRIES – Change up the summer berry routine with this power-packed fruit. Like most berries, mulberries are low in calories, but these winners also contain plenty of vitamin C, potassium, fiber, and the phytonutrient resveratrol, which has been shown to protect the heart.  

WHOLE GRAINS – While whole grains aren’t news, this research is: after analyzing the diets of more than 27,000 people across an eight-year span, Harvard University researchers found that those who ate whole grains daily weighed an average of 2.5 lbs less than those who ate only refined-grain foods. Researchers at Penn State University additionally found that those who ate whole grains lost 2.4 times more belly fat than their refined-grain-eating counterparts. This makes sense when considering how whole grains favorably affect blood-glucose levels, keeping your body from blood sugar spikes. Whole grains’ antioxidants help control inflammation and insulin (which the body uses to store belly fat).

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Science and Supplements – A Stacked Deck

As unbelievable as it sounds, current law makes it illegal for food producers to share certain types of scientific information with you.

So when Diamond Food relayed health information about the omega-3 fats in walnuts on product packaging and also on their Web site, the U.S. Food and Drug Administration (FDA) attacked.

Even though the information was entirely true, and backed by peer-reviewed scientific research.

This is the backward thinking that goes on at the FDA, where regulations currently prohibit manufacturers of dietary supplements or producers of food from referring to any scientific study documenting the potential effect of the substance on a health condition, punishable by large fines and even jail.

Disclosure about the benefits of a dietary supplement or food, no matter how credible, places the food in the category of an “unapproved drug.”  In other words, if a product makes a medical claim, it’s automatically classified as a drug.

The American Association for Health Freedom (AAHF) states:

“The FDA ignores first amendment protections and censors the communication of valid scientific information. The agency seems to have lost sight of its mandate to protect the public and has instead come to see itself as the guardian of corporate interests.”

And walnut producers are not alone. Cherry growers have also been threatened by the FDA with jail time if their websites even contain links to scientific studies from Harvard and elsewhere, outlining the health benefits of cherries for gout or arthritis pain.  Green tea growers have received similar threats. As I said, it truly boggles the mind…

Congressmen Jason Chaffetz (R–UT) and Jared Polis (D–CO) have introduced the Free Speech about Science Act (HR 1364), a landmark legislation that would allow the flow of legitimate scientific and educational information.  The new bill provides a limited and carefully targeted change to FDA regulations so that manufacturers and producers may reference legitimate, peer-reviewed scientific studies without converting a natural food or dietary supplement into an “unapproved drug.” According to Rep. Chaffetz’s website, the provisions of HR 1364 do the following:

  • Allow dietary supplements and healthy foods to cite legitimate scientific research
  • Provide a clear definition of the types of research that may be referenced by growers and manufacturers
  • Ensure that referencing such research does not convert a food or dietary supplement into an “unapproved (and therefore illegal) new drug”
  • Retain the authority of FDA and FTC to pursue any fraudulent and misleading statements

According to Rep. Chaffetz:

“It is important for individuals and families to take charge of their personal health by making the right decisions to get and stay healthy. This includes accessing information so that individuals can adjust habits, eat healthfully, and take appropriate dietary supplements to prevent and even treat health conditions.

The Free Speech About Science Act helps insure their access to legitimate scientific research to make the necessary decisions to improve their personal health and the health of their families.”

Rep. Polis adds:

“Today’s science has shown that vitamins and nutritional supplements can offer successful, natural alternatives to drugs. As we begin to reform our nation’s healthcare system, supplements are an innovative way to help reduce costs.

The Free Speech About Science Act is a common sense act that will make it easier for doctors and consumers to learn about the cheaper, healthier alternatives to costly medicines that food and nutritional supplements provide.”

As of December 2011, HR 1364 is in the first step in the legislative process and has been referred to committee. The majority of bills never make it out of committee, so we need your help.

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Priming Your Pump with Proper Nutrition

Fueling your body properly is a two-step process. It’s important to eat the right things – but it also makes a difference to eat at the right time. Men’s Health recently featured “A Day of Perfect Eating” on its website. Here are some of the tips given to help you perform to your prime:

  • Start your day with a protein-heavy breakfast within an hour of waking up. This revs your metabolism and will help keep you feeling full. Eggs are a great choice; protein fragments contained therein may curb blood pressure from rising.
  • If you’re feeling stressed out, set down your coffee cup and reach for a pack of gum. Chewing has been shown to reduce stress levels, possibly due to the motion’s positive association with mealtimes.
  • Focus need a boost? Have a mug of peppermint tea. Periodic whiffs of peppermint have been shown to improve concentration and performance on tasks requiring sustained attention.
  • Power your system with a lunch of salmon (or trout or halibut – these fish help keep you alert), blueberries (a great antioxidant), steak (the B-12 helps fight age-related brain shrinkage), garlic (which ups your brain’s serotonin and improves memory), or Brazil nuts (which has selenium that preserves cognitive functioning).
  • Turn up the heat to combat a headache. Capsaicin, which is what gives chilies their heat, can deplete the neurons that trigger headaches – but not by consumption. Instead, add a little cayenne powder to warm water and let it settle to the bottom. Then dip a swab of the solution inside your nostril on the side of the pain. It might burn a bit but is worth a try.
  • Keep your immune system strong with ginseng pills and foods rich in vitamin C. Canadian researchers found that people who took 400 mg of ginseng extract each day had 56 percent fewer recurring colds than their placebo-popping counterparts. Vitamin C’s been known to shorten the duration of symptoms when fighting a bug. Kiwis, oranges, and red bell peppers are great Vitamin C food options.
  • Need a quick snack before the gym? Eat half an apple and a shot of espresso for fast energy. According to Australian researchers, caffeine paired with carbohydrates boosts the rate at which the body replenishes its glycogen stores post-workout, compared with carbs alone.
  • Having a tough time falling asleep at the end of a long day? Drink some cherry juice. Carbohydrates can help boost your brain’s production of serotonin, helping you sleep deeply and well.

All of these ideas will provide significant changes in the way you feel, move, think, and live. Supplement with ASEA and you’ll enhance their efficiency even more!  Learn more about this breakthrough product and how it manages every cell in the body.

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Scientific Progress in Redox Biochemistry

Reactive oxygen species (ROS) and the reactive byproducts that these molecules generate are now recognized as serving physiological, as well as pathological, functions in cells and organisms.

With advances in detection methods, researchers are beginning to discover the molecular targets of these electrophilic molecules and to better appreciate their roles in regulating cellular behavior.

ROS and regulation of cellular behavior by ROS continue to be active areas of investigation with relevance to agriculture and human disease. Additionally, the diversity of the reactive species produced as by-products of reduction-oxidation reactions and the physiological, as well as pathological, roles these molecules play represent emerging fields of study that will likely rapidly expand as technologies for detecting these molecules improve and their targets are revealed.

Researchers have taken a first snapshot of how a class of highly reactive molecules inflicts cellular damage as part of aging, heart disease, stroke, cancer, diabetes, kidney disease and Alzheimer’s disease to name a few.

Reactive oxygen species (ROS), which include free radicals, are highly reactive molecules that force change upon many molecules they encounter. The body uses ROS to signal for wound healing and to destroy invaders. Excess amounts, however, damage sensitive cell components, including proteins and DNA, in a process called oxidative stress emphasizing the need for a balance of ROS and RS in the body.

Efforts to develop antioxidant drugs (e.g. vitamin E) to treat diseases of increased oxidative stress have met with limited success to date because they tried to eliminate ROS, rather than maintain the right amount again stressing the need for balance.

The reason ASEA is a breakthrough in this science is because it is the only stable and perfectly balanced mixture of ROS and RS molecules outside of the human body.  This perfectly balanced solution gives the body more of what it is trying to create on its own within every cell to maintain the balance the body needs to stay healthy.

As we age the cell’s ability to create these molecules on its own is diminished.  Until the process was discovered to create and stabilize these molecules outside of the body there was no way to supplement for this important physical requirement that gives the body the ability to heal itself.

Science is learning more and more about these molecules once thought to be a waste byproduct of the production of energy (ATP) in the cell.  As progress is made ASEA gains more and more validation and credibility.

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Rich Roll Media Tour Tomorrow

Rich Roll, elite ultra-endurance athlete and one of Men’s Health Magazine’s “25 Fittest Guys” will be appearing on major broadcast network television morning news programs across the county, talking about the amazing health benefits of ASEA and Redox Signaling Molecules.

Rich accomplished the staggering feat of endurance called the EPIC5 Challenge, completing 5 ironman-distance triathlons on 5 islands of Hawaii in under a week.  He has also been a top finisher at the Ultraman World Championships, a 3-day, 320 mile double-ironman distance triathlon.

Rich has been a passionate advocate of ASEA and has made it an integral part of his lifestyle, saying, “I am a big fan of the product, and feel it has significantly contributed to the advancement of not only my training and athletic performance, but also my overall wellness.”

You can read more about Rich and his passion for ASEA here.

 

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