This is a list of articles and papers on Redox Signaling from the science and medical communities.  This is some hardcore reading and is probably suited for doctors, scientists, and the nerdy (not meant in an offensive way I promise).

Enjoy the brain surge!

Critical Care 10(208) (2006), “Reactive oxygen species: toxic molecules or spark of life?”“, Shelden Magder.

Biochemical Pharmacology 70 (2005) 811-823, “Redox regulation: A new challenge for pharmacology”“, Daniel Frein, Stefan Schildknecht.

Redox signaling in biology and disease series intro, ““The expanding network of redox signaling: new observations, complexities and perspectives”“, Roy J. Soberman.

J Radiat Res (Tokyo 2004) 45(3) 357-72 “Oxidative stress, radiation-adaptive responses, and aging”“, Miura Y..

J Cell Bio: minireview, “Specificity in reactive oxidant signaling: think globally, act locally”“, Lance S. Terada.

Respir Res (2002) 3(26), “Oxygen-sensing mechanisms and regulation of redox-responsive transcription factors in development and pathophysiology”“,  Haddad JJ.

Biochemistry (Moscow) 70(2) (2005), ““Mitochondrial Metabolism of Reactive Oxygen Species”“, A Yu Andreyev.

Wound Rep Reg, v11 p431-438 (2003), “The general case for redox control of wound repair”, Chandan K. Sen.

Ther., v13(1), p211-220 (Jan 2006), “Dermal wound healing is subject to redox control”, Mol S. Roy, et al.

Fibrogenesis and tissue repair 1:5, “Redox mechanisms in hepatic chronic wound healing and fibrogenesis”, Erica Novo.

Antiox and Red Signaling, v10(2), p249-252 (2008), “Redox Imbalance and Lung Fibrosis”, Vuokko L. Kinnula.

Am J. Physiol Lung Cell Mol Physiol, v279, pL1005-L1028 (2000), “Reactive Oxygen Species in cell signaling”, Victor J. Thannickal and Barry L. Fanburg.

Exp. Physiol., v90(4), p457-462 (May 2005), “New aspects of artery resistance and structure: Oxidative Stress and Vascular Remodelling”, Ana Fortuno.

Cardiovascular Research, v71, p247-258 (2006), “Redox Signaling in Hypertension”, Tamara M Paravicini.

Hypertention, v44, p248-252 (Jul 2004), “Reactive Oxygen Species-Vascular oxidative stress and redox signaling in Hypertension, What is the clinical significance?”, Rhian M. Touyz.

Am J Physiol v275 pC1-C24 (1998), “Interaction of reactive oxygen species with ion transport mechanisms (an invited review)”, Joseph I. Kourie.

Arteriosclr Throm. Vasc. Biol., v20, p2175-2183 (2000), “Modulation of Protein Kinase Activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology”, Kathy K. Griendling, et al.

Neurochemical Research, v32(4-5), p757-773 (Dec 2006), “Redox Regulation of Cellular Stress Response in Aging and Neurodegenerative Disorders: Role of Vitagenes”, V. Calabrese, et al.

Prog. Neurobiol., v75(3), p207-246 (Feb 2005), “Oxidative stress in the brain: Novel targets that govern survival during neurodegenerative disease”, Zhao Zhong Chong, et al.

J of Medical Microbio, v52, p643-651 (2003), “Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte”, Emer P. Reeves.

N Engl J Med v298, p659-68 (1978), “Oxygen-dependent microbial killing by phagocytes (first of two parts)”, Babior BM.

Molec. Bio. of the Cell, v18, p2002-2012 (Jun 2007), “Superoxide Flux in Endothelial Cells via the Chloride Channel-3 Mediates Intracellular Signaling”, B.J. Hawkins, M. Madesh, C.J. Kirkpatrick, A.B. Fisher.

The J. of Cell Biology (JCB), v155(6), p1003-15 (Dec 2001), “VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release”, M. Madesh, G. Hajonczky.

Genes and Development, v15, p2922-2933 (2001), “The expanding role of mitochondria in apoptosis”, X. Wang.

Springer US Collections, Book: “ROS in Biological Systems Part VI”, Chapter: “ROS in Plants”, p481-501 (2007)

Redox Biochemistry, Wiley-Interscience, ed. Ruma Banerjee (2008)

Antioxidant and Redox Regulation of Genes, Academic Press, ed. Chandan K. Sen (2000)


The discovery of Redox Signaling Molecules and eventual ability to stabilize them in a solution outside the human body has taken nearly two decades to accomplish.  ASEA is the product of this discovery and the millions of dollars and years of research spent to date.

This page is for those who enjoy hard data.  The links here will provide you with data accumulated to date and available to the public on the product branded as ASEA.  As more data becomes available it will be posted here.

White Paper on Bioactivity of ASEA

White Paper on Athletic Performance based on VO2max Tests

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