Study Shows Signaling Pathways in Genes After Consuming Redox Supplement

Redox Signaling MoleculesThe results of double-blind placebo based study on a Utah company’s Redox cell signaling supplement are in.

This initial study shows a unique Redox signaling supplement can signal human genes, which have “shut off” due to stress, toxins, age, etc., and turn them back on.

The company, ASEA Global, owns numerous patents on this new technology. They partnered with Taueret Laboratories, a leading genetic research laboratory, to conduct an observational study to understand how this Redox Signaling supplement affects the activation of human genes. The eight-week human study was reviewed and approved by Quorum Review Independent Review Board, ensuring the ethical integrity, safety, and control of the research study. The study was a randomized double-blind placebo controlled study.

60 participants were randomly placed into three groups, 25 in an active group (REDOX supplement), 25 in a placebo group (saline placebo), and 10 in a control group (did not drink either the REDOX supplement or the placebo). The placebo was derived from the same saline solution used to create the actual REDOX supplement for this study, but did not contain the company’s patented redox molecules.

Of the 60 participants, 41% were male and 59% were female, with the mean age 35.  Each participant, except for the control group, drank 4 ounces of REDOX supplement or placebo twice daily.

Participants had blood drawn at the beginning of the study and again at week eight of the study. Serum RNA was extracted using a PreAnalytix PAXgene Blood RNA Kit. Gene expression levels were then tested using Affymetrix PrimeView Array and differential expression within and between groups analyzed.


Results of the eight-week study showed a 20 – 31% difference in gene expression abundance in five genes that are involved in pathway signaling, including regulatory network pathways. Long-term consumption of the REDOX supplement resulted in stable expression changes at the eight-week time point (figure 1). These genes are key in the health of the individual and play a vital role in five human health areas and dozens of pathways.

Pathway signaling genes are unique as they have the potential to influence a multitude of biological responses. Analysis of the five genes was provided through two pathway analysis programs, PANTHER (Protein ANalysis THrough Evolutionary Relationships) and WikiPathways. An example of a gene product that was expressed in this study that interacts with multiple important pathways is the EGR1 gene.

In order to better understand how the genes reacted post-study, the REDOX supplement group that saw the 20 – 31% change provided blood samples eight weeks post-study. The results demonstrated that all the changes seen while on the product had reverted back to their pre-study levels.


• The initial study data suggests that five genes expressed a change in transcript abundance.

• The REDOX supplement group saw gene activation results in regulatory pathway related genes that signal dozens of  important biological functions.

• The REDOX supplement and the placebo (saline) behaved differently.

• There were no harmful changes in the gene expression trends of the participants consuming either beverage during the course of the study. This is representative of long-term safety.

• Daily consumption of REDOX supplement over eight weeks  appears to result in stable expression changes.

• Changes in gene expression eight weeks post study in the REDOX supplement group were no longer observed. This suggests continued use of REDOX supplement is necessary to  sustain the observed gene expression results.

• Effects of consuming REDOX supplement are systemic.

• Effects are non-specific to race, sex or age, and were observed in all populations tested.

This entry was posted in Anti-Aging, Health and Wellness, Preventative Health, Redox Signaling and tagged , , , , , . Bookmark the permalink.

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